EFFECT OF HEPARIN ON THE INHIBITION OF THROMBIN BY ALPHA-1-PROTEINASE INHIBITOR

被引：21

作者：

DANISHEFSKY, I

PIXLEY, R

机构：

[1] Department of Biochemistry, New York Medical College Valhalla

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 91卷 / 03期

关键词：

D O I：

10.1016/0006-291X(79)91959-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Heparin interferes with the inhibition of thrombin by α1-proteinase inhibitor (αPI). The inhibitory effect of heparin is due to its binding to thrombin. Other glycosaminoglycans and carboxyl-modified heparin do not have the same effect as heparin. The results indicate that there are similarities in the structural requirements in heparin, for anticoagulant activity and for the inhibition of αPI interaction with thrombin. © 1979.

引用

页码：862 / 870

页数：9

共 24 条

[1]

BLOOM JW, 1978, J BIOL CHEM, V253, P547

[2] P-NITROPHENYL-P'-GUANIDINOBENZOATE HCL - A NEW ACTIVE SITE TITRANT FOR TRYPSIN [J].