PHENOBARBITAL DOSES NECESSARY TO ACHIEVE THERAPEUTIC CONCENTRATIONS IN CHILDREN

被引：4

作者：

SUZUKI, Y ^{[1
]}

COX, S ^{[1
]}

HAYES, J ^{[1
]}

WALSON, PD ^{[1
]}

机构：

[1] CHILDRENS HOSP,DIV CLIN PHARMACOL TOXICOL,COLUMBUS,OH 43205

来源：

DEVELOPMENTAL PHARMACOLOGY AND THERAPEUTICS | 1991年 / 17卷 / 1-2期

关键词：

PHENOBARBITAL; INFANT; CHILDREN; DOSE; DOSE RATIO; CONCENTRATION;

D O I：

10.1159/000457502

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Steady-state plasma phenobarbital (PB) concentrations (n = 671) were measured in 438 inpatients. There was a significant relationship between age and PB dose ratio (concentration/dose or 1/clearance) for monotherapy patients; the dose ratio declined in the first year of life, but the dose ratio increased after age 1. The dose ratios were significantly higher in patients receiving PB in combination with other antiepileptic drugs. However, neither sex nor formulations used (tablet, elixir and intravenous) had any influence on the PB dose ratio. The age-dose-concentration relationships indicate that children, especially those under 11 years of age, may require maintenance PB doses more than 5 mg/kg/day to achieve the commonly recommended 'therapeutic' concentration range (10-40 mg/1).

引用

页码：79 / 87

页数：9

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