ROLIPRAM INHIBITS PAF-INDUCED AIRWAY MICROVASCULAR LEAKAGE IN GUINEA-PIG - A COMPARISON WITH MILRINONE AND THEOPHYLLINE

被引：18

作者：

ORTIZ, JL ^{[1
]}

CORTIJO, J ^{[1
]}

VALLES, JM ^{[1
]}

BOU, J ^{[1
]}

MORCILLO, EJ ^{[1
]}

机构：

[1] LABS ALMIRALL SA,DEPT FARMACOL,BARCELONA,SPAIN

来源：

FUNDAMENTAL & CLINICAL PHARMACOLOGY | 1992年 / 6卷 / 06期

关键词：

ROLIPRAM; VASCULAR PERMEABILITY; GUINEA-PIG AIRWAY;

D O I：

10.1111/j.1472-8206.1992.tb00117.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of 3 phosphodiesterase (PDE) inhibitors, rolipram (PDE IV), milrinone (PDE III) and theophylline (non-selective) on PA.F (50 ng kg-1; iv)-induced airway vascular leakage have been evaluated in guinea-pigs. Rolipram (3-300 mug kg-1; iv) reduced the increase in permeability induced by PAF at all airway levels whereas milrinone (10-1000 mug kg-1 ; iv) and theophylline (30 mg kg-1; iv) were without effects. The anti-leakage activity of rolipram may be of therapeutic value in asthma.

引用

页码：247 / 249

页数：3

共 6 条

[1] EFFECT OF ANTIASTHMA DRUGS ON MICROVASCULAR LEAKAGE IN GUINEA-PIG AIRWAYS [J].