PAF ACTIVATION OF A VOLTAGE-GATED R-TYPE CA(2+) CHANNEL IN HUMAN AND CANINE AORTIC ENDOTHELIAL-CELLS

被引：43

作者：

BKAILY, G

DORLEANSJUSTE, P

NAIK, R

PERODIN, J

STANKOVA, J

ABDULNOUR, E

ROLAPLESZCZYNSKI, M

机构：

[1] UNIV SHERBROOKE,FAC MED,DEPT IMMUNOL,SHERBROOKE J1H 5N4,QUEBEC,CANADA

[2] UNIV SHERBROOKE,FAC MED,DEPT PHARMACOL,SHERBROOKE J1H 5N4,QUEBEC,CANADA

[3] UNIV SHERBROOKE,FAC MED,DEPT SURG,SHERBROOKE J1H 5N4,QUEBEC,CANADA

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1993年 / 110卷 / 02期

关键词：

ENDOTHELIAL CELLS; CA(2+) CHANNEL; PAF; CALCIUM BLOCKERS; CALCIUM;

D O I：

10.1111/j.1476-5381.1993.tb13841.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

By the use of fura-2 and digital imaging techniques, [K]o depolarization or PAF (10(-9)M) were shown to induce a sustained increase of [Ca]i in human or canine single aortic vascular endothelial cells (VEC) that was insensitive to nifedipine but sensitive to (-)-PN200-110 or to lowering of [Ca]o. The PAF-induced effect on [Ca]i was blocked by the PAF receptor antagonist, WEB2170. Our results suggest that [K]o depolarization and PAF increase [Ca]i via the activation of R-type Ca2+ channels.

引用

页码：519 / 520

页数：2

共 8 条

[1]

BKAILY G, 1992, MOL CELL BIOCHEM, V117, P93

[2]

BKAILY G, 1991, ION CHANNELS VASCULA, P185

[3] VOLTAGE-GATED AND RECEPTOR-MEDIATED IONIC CURRENTS IN THE MEMBRANE OF ENDOTHELIAL-CELLS [J].