ENDOGENOUS GAMMA-INTERFERON MEDIATES RESISTANCE TO BRUCELLA-ABORTUS INFECTION

被引：156

作者：

ZHAN, YF

CHEERS, C

机构：

来源：

INFECTION AND IMMUNITY | 1993年 / 61卷 / 11期

关键词：

D O I：

10.1128/IAI.61.11.4899-4901.1993

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Depletion of endogenous gamma interferon (IFN-gamma) with anti-IFN-gamma monoclonal antibody resulted in increased numbers of Brucella abortus in the spleen and liver of infected CBA mice. This increase was accompanied by a decrease in splenomegaly and a lower proportion of macrophages in the spleen. Furthermore, treatment of recipient mice with anti-IFN-gamma antibody blocked the adoptive transfer of resistance with immune T cells. Together, the results indicated that endogenous IFN-gamma plays an important role in mediating resistance to primary and secondary Brucella infection.

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页码：4899 / 4901

页数：3

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