INHIBITORS OF PROTEIN-KINASES AND PHOSPHATASES

被引：228

作者：

MACKINTOSH, C

MACKINTOSH, RW

机构：

[1] C. MacKintosh and R.W. MacKintosh are, the Medical Research Council Protein Phosphorylation Unit, Department of Biochemistry, Dundee

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1994年 / 19卷 / 11期

关键词：

D O I：

10.1016/0968-0004(94)90127-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inhibitors of eukaryotic protein kinases and phosphatases are a chemically diverse array of natural and synthetic compounds, including medicines, potions and poisons. These substances are valuable pharmacological probes and affinity ligands for the kinases and phosphatases of signalling pathways, enhancing our knowledge of the cellular effects of the pathway in question. More broadly, this basic research is also leading to the development of drugs to control specific cellular responses, and enzyme-based assays to detect toxins in food and water.

引用

页码：444 / 448

页数：5

共 35 条

[1]

AKIYAMA T, 1991, METHOD ENZYMOL, V201, P362

[2]

ALBERS MW, 1993, J BIOL CHEM, V268, P22825

[3] MUTATION-INDUCTION BY OKADAIC ACID, A PROTEIN PHOSPHATASE INHIBITOR, IN CHL CELLS, BUT NOT IN SALMONELLA-TYPHIMURIUM [J].

AONUMA, S ;

USHIJIMA, T ;

NAKAYASU, M ;

SHIMA, H ;

SUGIMURA, T ;

NAGAO, M .

MUTATION RESEARCH, 1991, 250 (1-2) :375-381

[4] INHIBITORS OF PROTEIN-KINASE-C .3. POTENT AND HIGHLY SELECTIVE BISINDOLYLMALEIMIDES BY CONFORMATIONAL RESTRICTION [J].

BIT, RA ;

DAVIS, PD ;

ELLIOTT, LH ;

HARRIS, W ;

HILL, CH ;

KEECH, E ;

KUMAR, H ;

LAWTON, G ;

MAW, A ;

NIXON, JS ;

VESEY, DR ;

WADSWORTH, J ;

WILKINSON, SE .

JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (01) :21-29

[5] THERAPEUTIC POTENTIAL OF PROTEIN-KINASE-C INHIBITORS [J].

BRADSHAW, D ;

HILL, CH ;

NIXON, JS ;

WILKINSON, SE .

AGENTS AND ACTIONS, 1993, 38 (1-2) :135-147

[6] A MAMMALIAN PROTEIN TARGETED BY G1-ARRESTING RAPAMYCIN-RECEPTOR COMPLEX [J].

BROWN, EJ ;

ALBERS, MW ;

SHIN, TB ;

ICHIKAWA, K ;

KEITH, CT ;

LANE, WS ;

SCHREIBER, SL .

NATURE, 1994, 369 (6483) :756-758

[7] TOXINS OF CYANOBACTERIA [J].

CARMICHAEL, WW .

SCIENTIFIC AMERICAN, 1994, 270 (01) :78-86

[8] THE DISCOVERY OF PROTEIN PHOSPHATASES - FROM CHAOS AND CONFUSION TO AN UNDERSTANDING OF THEIR ROLE IN CELL REGULATION AND HUMAN-DISEASE [J].

COHEN, P .

BIOESSAYS, 1994, 16 (08) :583-588

[9] OKADAIC ACID - A NEW PROBE FOR THE STUDY OF CELLULAR-REGULATION [J].

COHEN, P ;

HOLMES, CFB ;

TSUKITANI, Y .

TRENDS IN BIOCHEMICAL SCIENCES, 1990, 15 (03) :98-102

[10] PI-3-KINASE IS A DUAL-SPECIFICITY ENZYME - AUTOREGULATION BY AN INTRINSIC PROTEIN-SERINE KINASE-ACTIVITY [J].

DHAND, R ;

HILES, I ;

PANAYOTOU, G ;

ROCHE, S ;

FRY, MJ ;

GOUT, I ;

TOTTY, NF ;

TRUONG, O ;

VICENDO, P ;

YONEZAWA, K ;

KASUGA, M ;

COURTNEIDGE, SA ;

WATERFIELD, MD .

EMBO JOURNAL, 1994, 13 (03) :522-533

← 1 2 3 4 →