HIPPOCAMPAL LONG-TERM DEPRESSION - ARACHIDONIC-ACID AS A POTENTIAL RETROGRADE MESSENGER

被引：49

作者：

BOLSHAKOV, VY

SIEGELBAUM, SA

机构：

[1] Center for Neurobiology and Behavior, Department of Pharmacology, Howard Hughes Medical Institute, New York, NY 10032

来源：

NEUROPHARMACOLOGY | 1995年 / 34卷 / 11期

关键词：

HIPPOCAMPUS; LONG-TERM DEPRESSION (LTD); ARACHIDONIC ACID; RETROGRADE MESSENGER;

D O I：

10.1016/0028-3908(95)00127-R

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Long-term depression (LTD) was studied in hippocampal slices from neonatal rats at the synapse between CA3 and CA1 pyramidal neurons. The induction of LTD requires the pairing of Ca2+ influx into the postsynaptic CA1 neuron through voltage-gated calcium channels with activation of metabotropic glutamate receptors. The expression of this LTD is at least partly presynaptic, implying the need for a retrograde messenger. We present evidence that arachidonic acid might serve such a function. Thus, arachidonic acid applications simulate LTD whereas blockade of arachidonic acid release inhibits LTD.

引用

页码：1581 / 1587

页数：7

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