QSAR IN TOXICOLOGY .2. PREDICTION OF ACUTE MAMMALIAN TOXICITY AND INTERSPECIES CORRELATIONS

A critical review is given of quantitative structure-activity relationships (QSAR) for the prediction of mammalian toxicological endpoints. QSAR predictions for mammalian toxicity are generally poorly developed although hydrophobicity correlates well with the toxicity of unreactive chemicals. Interspecies correlations of acute toxicity are discussed and when the mode of toxic action is taken into account these may provide a valuable source of information for comparative toxicity and the potential use of surrogate species for testing.