PALLADIUM(II) AND PLATINUM(II) COMPLEXES WITH THE LIGAND SE=P(NME2)3

Pd(II) and Pt(II) with the ligand [(CH32N]3PSe afford complexes of the formula trans-ML2Cl2, in which the ligand is co-ordinated through the Se atom. The complexes in solution undergo ligand elimination and convert into the dimers [MLCl2]2, which have been prepared by an independent route. The complex [PdLCl2]2 in the presence of free ligand affords cis-PdL2Cl2. The Pt(II) complexes trans-PtL2Cl2 and [PtLCl2]2 induce E. Coli elongation at low concentrations (2-6 ppm) and have been found to be active as antimitotic agents against cultures in vitro of tumorigenic cells (Mice Fibroblasts LS) and to inhibit DNA, RNA and protein synthesis. The complex [PdL′Cl2]2 [L′ = P(NMe2)3] has been also prepared. © 1979.