FEMALES DHT CONTROLS SEX-DIFFERENCES IN THE RAT BED NUCLEUS OF THE ACCESSORY OLFACTORY TRACT

被引：15

作者：

COLLADO, P ^{[1
]}

SEGOVIA, S ^{[1
]}

CALES, JM ^{[1
]}

LASO, CP ^{[1
]}

ZAFRA, MR ^{[1
]}

GUILLAMON, A ^{[1
]}

VALENCIA, A ^{[1
]}

机构：

[1] UNIV NACL EDUC DISTANCIA,DEPT PSICOBIOL,E-28040 MADRID,SPAIN

来源：

NEUROREPORT | 1992年 / 3卷 / 04期

关键词：

DIHYDROTESTOSTERONE; CYPROTERONE ACETATE; SEX DIFFERENCES; BED NUCLEUS OF THE ACCESSORY OLFACTORY TRACT; VOMERONASAL SYSTEM; RAT;

D O I：

10.1097/00001756-199204000-00009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

IN the present study the regulatory action of the non-aromatic androgen dihydrotestosterone (DHT) on the volume of the sexually dimorphic bed nucleus of the accessory olfactory tract (BAOT) was investigated. Postnatal treatment with DHT (180-mu-g day-1) between days 6 and 20 (D6-D20) induced, in gonadally intact male rats, a drastic reduction in the overall volume to levels typical in control females. Conversely, the postnatal administration of the anti-androgen cyproterone acetate (CA) to the females from D6-D20 produced an increment in the BAOT volume not dissimilar to that found in control males. These findings reveal that sexual organization in this vomeronasal structure is dependant on the presence of DHT in females during postnatal development.

引用

页码：327 / 329

页数：3

共 26 条

[1] GONADAL-STEROID INDUCTION OF STRUCTURAL SEX-DIFFERENCES IN THE CENTRAL NERVOUS-SYSTEM [J].

ARNOLD, AP ;

GORSKI, RA .

ANNUAL REVIEW OF NEUROSCIENCE, 1984, 7 :413-442

[2]

BAYER SA, 1983, EXP BRAIN RES, V50, P329

[3] QUANTITATIVE THYMIDINE-H-3 RADIOGRAPHIC ANALYSES OF NEUROGENESIS IN THE RAT AMYGDALA [J].

BAYER, SA .

JOURNAL OF COMPARATIVE NEUROLOGY, 1980, 194 (04) :845-875

[4] SEXUAL DIMORPHISM IN THE BED NUCLEUS OF THE ACCESSORY OLFACTORY TRACT IN THE RAT [J].

COLLADO, P ;

GUILLAMON, A ;

VALENCIA, A ;

SEGOVIA, S .

DEVELOPMENTAL BRAIN RESEARCH, 1990, 56 (02) :263-268

[5]

DAVIS BJ, 1978, BRAIN RES BULL, V3, P59, DOI 10.1016/0361-9230(78)90062-X

[6] BILATERAL LESIONS OF THE BED NUCLEUS OF THE ACCESSORY OLFACTORY TRACT FACILITATE MATERNAL-BEHAVIOR IN VIRGIN FEMALE RATS [J].

DELCERRO, MCR ;

IZQUIERDO, MAP ;

COLLADO, P ;

SEGOVIA, S ;

GUILLAMON, A .

PHYSIOLOGY & BEHAVIOR, 1991, 50 (01) :67-71

[7] SEX-DEPENDENT CHANGES IN PITUITARY 5ALPHA-DIHYDROTESTOSTERONE AND 3ALPHA-ANDROSTANEDIOL FORMATION DURING POSTNATAL-DEVELOPMENT AND PUBERTY IN RAT [J].

DENEF, C ;

MAGNUS, C ;

MCEWEN, BS .

ENDOCRINOLOGY, 1974, 94 (05) :1265-1274

[8]

DENEF C, 1984, METABOLISM HORMONAL, V13, P53

[9] AFFERENT CONNECTIONS OF MAIN AND ACCESSORY OLFACTORY-BULB FORMATIONS IN RAT - EXPERIMENTAL HRP-STUDY [J].

DEOLMOS, J ;

HARDY, H ;

HEIMER, L .

JOURNAL OF COMPARATIVE NEUROLOGY, 1978, 181 (02) :213-244

[10]

DEOLMOS J, 1985, RAT NERVOUS SYSTEM, V1, P223

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