FAMILIAL AND SPORADIC INSULIN-DEPENDENT DIABETES - EVIDENCE FOR HETEROGENEOUS ETIOLOGIES

被引:33
作者
OLEARY, LA
DORMAN, JS
LAPORTE, RE
ORCHARD, TJ
BECKER, DJ
KULLER, LH
EBERHARDT, MS
CAVENDER, DE
RABIN, BS
DRASH, AL
机构
[1] CHILDRENS HOSP,DEPT PEDIAT,DIV ENDOCRINOL & METAB,PITTSBURGH,PA 15213
[2] UNIV PITTSBURGH,PITTSBURGH,PA 15260
[3] NATL CTR HLTH STAT,CTR DIS CONTROL,DIV EPIDEMIOL & HLTH PROMOT,HYATTSVILLE,MD 20782
[4] UNIV MIAMI,SCH MED,DEPT MICROBIOL & IMMUNOL,MIAMI,FL 33152
[5] UNIV PITTSBURGH,SCH MED,DEPT PATHOL,PITTSBURGH,PA 15261
关键词
INSULIN-DEPENDENT DIABETES-MELLITUS; ETIOLOGY; EPIDEMIOLOGY; FAMILIAL; SPORADIC;
D O I
10.1016/0168-8227(91)90019-A
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Heterogeneity within insulin-dependent diabetes mellitus (IDDM) has been hypothesized, but few studies have focused on differences which may exist between familial and sporadic IDDM cases. Presenting characteristics for 330 white, newly diagnosed IDDM cases were evaluated. Familial cases were older (10.2 +/- 5.1 years vs 7.9 +/- 4.2 years, P = 0.010) and had, on average, less severe metabolic disturbances at presentation, as demonstrated by lower mean hemoglobin A1 (12.6 +/- 2.4% vs 14.4 +/- 2.6%, P = 0.001) and mean insulin dose at discharge (0.62 +/- 0.35 U/kg/day vs 0.85 +/- 0.29 U/kg/day, P < 0.001), and higher mean plasma bicarbonate concentrations (19.3 +/- 3.9 mmol/l vs 15.8 +/- 5.9 mmol/l, P = 0.023) and mean plasma C-peptide levels (0.35 +/- 0.36 pmol/ml vs 0.14 +/- 0.15 pmol/ml, P < 0.001). Further analyses on a subset of IDDM cases (n = 100) indicated that initial differences in metabolic indices observed at diagnosis were no longer apparent at one-year post-diagnosis. These results suggest that the etiology of familial and sporadic IDDM is similar and that the less severe presentation observed at diagnosis in the familial cases may be due to earlier identification of the disease, reflecting increased parental knowledge of diabetic symptoms and/or frequent testing for diabetes.
引用
收藏
页码:183 / 190
页数:8
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