HEPATIC TRANSPORT OF THE MAGNETIC-RESONANCE-IMAGING CONTRAST AGENT FE(III)-N-(3-PHENYLGLUTARYL)DESFERRIOXAMINE-B

被引：8

作者：

HOENER, BA ^{[1
]}

TZIKA, AA ^{[1
]}

ENGLESTAD, BL ^{[1
]}

WHITE, DL ^{[1
]}

机构：

[1] UNIV CALIF SAN FRANCISCO,SCH MED,DEPT RADIOL,SAN FRANCISCO,CA 94143

来源：

MAGNETIC RESONANCE IN MEDICINE | 1991年 / 17卷 / 02期

关键词：

D O I：

10.1002/mrm.1910170221

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

We have studied the hepatic transport of Fe(III)‐N‐(3‐phenylglutaryl)desferrioxamine B (Fe‐PGDF). Using 59Fe‐PGDF in biliary cannulated rats we have shown that 32 ± 2% of an iv bolus dose was excreted into the bile. In animals pretreated with a saturating dose of taurocholate, oxyphenonium, or bromosulfophthalein (BSP), 25 ± 6%, 23 ± 1%, or 1.6 ± 0.8% of the dose, respectively, was excreted into the bile. Magnetic resonance images indicated that BSP blocked uptake of Fe‐PGDF by the hepatocytes. Possible enterohepatic recycling of 59Fe‐PGDF was investigated in linked rat experiments. All of the material excreted into the bile of the donor, 28 ± 10% of the dose, was recovered in the gastrointestinal tract of the recipient, but none was found in its bile or urine. These results suggested that uptake of Fe‐PGDF by the hepatocytes occurred via the BSP transporter and that no enterohepatic recycling of the contrast agent occurred. © 1991 Academic Press, Inc. Copyright © 1991 Wiley‐Liss, Inc., A Wiley Company

引用

页码：509 / 515

页数：7