SYNTHESIS OF UNSATURATED TRICYCLIC LACTONES - THE COUPLING OF THE ENOL TRIFLATE OF BETA-KETO LACTONES WITH LITHIUM DIMETHYLCUPRATE

被引:8
作者
BACIGALUPPO, JA [1 ]
COLOMBO, MI [1 ]
ZINCZUK, J [1 ]
RUVEDA, EA [1 ]
机构
[1] FAC CIENCIAS BIOQUIM & FARMACEUT,UNR,CONICET,INST QUIM ORGAN SINTESIS,CASILLA CORREO 991,RA-2000 ROSARIO,ARGENTINA
关键词
D O I
10.1080/00397919208021329
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The anions of selected beta-keto lactones were transformed into their corresponding enol triflates. These enol triflates were coupled with lithium dimethylcuprate to afford tricyclic unsaturated lactones, key intermediates for the synthesis of the biologically important natural product forskolin.
引用
收藏
页码:1973 / 1984
页数:12
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