A NEW ENZYMATIC-REACTION - ENZYME-CATALYZED AMMONOLYSIS OF CARBOXYLIC ESTERS

被引：32

作者：

DEZOETE, MC

KOCKVANDALEN, AC

VANRANTWIJK, F

SHELDON, RA

机构：

[1] Delft University of Technology, Laboratory of Organic Chemistry and Catalysis, 2628, BL, Delft

来源：

BIOCATALYSIS | 1994年 / 10卷 / 1-4期

关键词：

AMMONOLYSIS; AMMONIA; CARBOXYLIC ACIDS; CARBOXYLIC ESTERS; CARBOXYLIC AMIDES; HYDROLASES; LIPASES; ENANTIOSELECTIVITY;

D O I：

10.3109/10242429409065240

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new enzymatic reaction of carboxylic esters and ammonia (ammonolysis) was studied. This reaction provides a synthetically useful and mild alternative for the synthesis of amides. Several lipases and one esterase acted as catalyst. Ammonolysis of esters of chiral carboxylic acids gave higher ee values than hydrolysis under comparable reaction conditions. Furthermore, consecutive enzymatic esterification and ammonolysis provided a convenient one-pot synthesis of carboxylic amides from carboxylic acids.

引用

页码：307 / 316

页数：10

共 11 条

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