SYNTHESIS OF ESTER DERIVATIVES OF CHLORAMPHENICOL BY LIPASE-CATALYZED TRANSESTERIFICATION IN ORGANIC-SOLVENTS

被引：45

作者：

OTTOLINA, G ^{[1
]}

CARREA, G ^{[1
]}

RIVA, S ^{[1
]}

机构：

[1] CNR,IST CHIM ORMONI,VIA MARIO BIANCO 9,I-20133 MILAN,ITALY

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1990年 / 55卷 / 08期

关键词：

D O I：

10.1021/jo00295a025

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Regioselective esterification of chloramphenicol (1) and its synthetic analogue thiamphenicol (2) has been achieved bythe action of lipase in acetone and several methyl carboxylates. Aliphatic and aromatic esters of different sizes and natures have been introduced selectively on the primary hydroxyl group of these molecules by modification of the reaction conditions (e.g., temperature, solvent, and lipase source). © 1990, American Chemical Society. All rights reserved.

引用

页码：2366 / 2369

页数：4

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