ANTI-PARASITIC AGENTS .3. SYNTHESIS AND ANTHELMINTIC ACTIVITIES OF NOVEL 2-PYRIDINYL-5-ISOTHIOCYANATOBENZIMIDAZOLES

被引：31

作者：

HAUGWITZ, RD ^{[1
]}

MAURER, BV ^{[1
]}

JACOBS, GA ^{[1
]}

NARAYANAN, VL ^{[1
]}

CRUTHERS, L ^{[1
]}

SZANTO, J ^{[1
]}

机构：

[1] SQUIBB AGR RES CTR,THREE BRIDGES,NJ

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1979年 / 22卷 / 09期

关键词：

D O I：

10.1021/jm00195a021

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The preparation and anthelmintic activities of a series of 2-pyridinyl-5-isothiocyanatobenzimida7.oles are described. In the primary oral mouse screen, six derivatives showed 100% taeniacidal activity at 0.2% in diet. The most active member in this series, 1c, is potentially an effective gastrointestinal nematocide in sheep at 50 mg/kg po. © 1979, American Chemical Society. All rights reserved.

引用

页码：1113 / 1118

页数：6

共 27 条

[1]

AHMED SH, 1975, FORTSCHR ARZNEIMITTE, V19, P2

[2]

BRENNEISEN P, Patent No. 1935338

[3]

BRENNEISSEN P, Patent No. 2225071

[4] ANTIPARASITIC DRUGS .4. 2-(4'-THIAZOLYL)-BENZIMIDAZOLE, A NEW ANTHELMINTIC [J].