STRUCTURE-ACTIVITY-RELATIONSHIPS OF AROMATIC-AMINES IN THE AMES SALMONELLA-TYPHIMURIUM ASSAY

被引：19

作者：

KALOPISSIS, G

机构：

[1] Laboratoires de Recherche, Société L'Oréal, Neuilly sur Seine

来源：

MUTATION RESEARCH | 1991年 / 246卷 / 01期

关键词：

STRUCTURE ACTIVITY RELATIONSHIP; MUTAGENICITY; BENZENE AMINES; ELECTRONIC AND STERIC EFFECTS;

D O I：

10.1016/0027-5107(91)90107-Y

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The author tried in a somewhat limited work to quantitatively correlate the electronic and steric intramolecular interactions of substituents on the amino group (influencing the enzymatic reactions of aromatic amines) and the mutagenic event. It was assumed that there is a correlation between these biotransformations and the electronic state of aromatic amines at the ionic dissociation equilibrium. The approach is rather empirical and arbitrary but the overall agreement between experimental mutagenic potencies and the values calculated was encouraging and led the author to further developments. It is hoped that the concepts used in this work may be applied to other aromatic molecules bearing an amino group.

引用

页码：45 / 66

页数：22

共 56 条

[1] METHODS FOR DETECTING CARCINOGENS AND MUTAGENS WITH SALMONELLA-MAMMALIAN-MICROSOME MUTAGENICITY TEST [J].