A nationwide epidemiological survey of chronic hypersensitivity pneumonitis in Japan

被引：59

作者：

Okamoto, Tsukasa ^{[1
]}

Miyazaki, Yasunari ^{[1
]}

Ogura, Takashi ^{[2
,3
]}

Chida, Kingo

Kohno, Nobuoki ^{[4
]}

Kohno, Shigeru ^{[5
]}

Taniguchi, Hiroyuki ^{[6
]}

Akagawa, Shinobu ^{[7
]}

Mochizuki, Yoshiro ^{[8
]}

Yamauchi, Kohei ^{[9
]}

Takahashi, Hiroki ^{[10
]}

Johkoh, Takeshi ^{[11
]}

Homma, Sakae ^{[12
]}

Kishi, Kazuma ^{[13
]}

Ikushima, Soichiro ^{[14
]}

Konno, Satoshi ^{[15
]}

Mishima, Michiaki ^{[16
]}

Ohta, Ken ^{[17
]}

Nishioka, Yasuhiko ^{[18
]}

Yoshimura, Nobuyuki ^{[19
,20
]}

Munakata, Mitsuru

Watanabe, Kentaro ^{[21
]}

Miyashita, Yoshihiro ^{[1
,22
]}

机构：

[1] Tokyo Med & Dent Univ, Dept Integrated Pulmonol, Bunkyo Ku, 1-5-45,Yushima, Tokyo 1138519, Japan

[2] Kanagawa Cardiovasc & Resp Ctr, Dept Resp Med, Kanagawa Ku, Yokohama, Kanagawa 2360051, Japan

[3] Hamamatsu Univ Sch Med, Dept Resp Med, Higashi Ku, Hamamatsu, Shizuoka 4313192, Japan

[4] Hiroshima Univ, Dept Mol & Internal Med, Minami Ku, Hiroshima, Hiroshima 7348551, Japan

[5] Nagasaki Univ, Dept Internal Med 2, Nagasaki, Nagasaki 8528501, Japan

[6] Tosei Gen Hosp, Dept Resp Med & Allergy, Seto City, Aichi 4898642, Japan

[7] Tokyo Natl Hosp, Natl Hosp Org, Dept Resp Med, Kiyose, Tokyo 2048585, Japan

[8] Himeji Med Ctr, Dept Internal Med, Himeji, Hyogo 6708520, Japan

[9] Iwate Med Univ, Dept Internal Med, Morioka, Iwate 0208505, Japan

[10] Sapporo Med Univ, Dept Internal Med, Chuo Ku, Sapporo, Hokkaido 0608543, Japan

[11] Kinki Cent Hosp, Dept Radiol, Itami, Hyogo 6648533, Japan

[12] Toho Univ, Dept Resp Med, Ota Ku, Tokyo 1438541, Japan

[13] Toranomon Gen Hosp, Dept Resp Med, Minato Ku, Tokyo 1058470, Japan

[14] Japanese Red Cross Med Ctr, Dept Resp Med, Shibuya Ku, Tokyo 1508935, Japan

[15] Hokkaido Univ, Dept Med 1, Kita Ku, Sapporo, Hokkaido 0608648, Japan

[16] Kyoto Univ, Dept Resp Med, Sakyo Ku, Kyoto, Kyoto 6068507, Japan

[17] Teikyo Univ, Dept Internal Med, Itabashi Ku, Tokyo 1730003, Japan

[18] Univ Tokushima, Dept Resp Med, Tokushima, Tokushima 7708503, Japan

[19] Hiratsuka Kyosai Hosp, Dept Resp Med, Hiratsuka, Kanagawa 2548502, Japan

[20] Fukushima Med Univ, Dept Pulm Med, Fukushima, Fukushima 9601295, Japan

[21] Fukuoka Univ, Dept Resp Med, Jonan Ku, Fukuoka, Fukuoka 8140180, Japan

[22] Yamanashi Prefectural Cent Hosp, Dept Resp Med, Kofu, Yamanashi 4008506, Japan

来源：

RESPIRATORY INVESTIGATION | 2013年 / 51卷 / 03期

关键词：

Hypersensitivity pneumonitis; Extrinsic allergic alveolitis; Pulmonary fibrosis; Surveillance;

D O I：

10.1016/j.resinv.2013.03.004

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Background: In 1999, a Japanese epidemiological survey of chronic hypersensitivity pneumonitis (HP) showed that summer-type HP was the most prevalent variant of the disease. The number of reported cases of chronic HP has recently been increasing, and the clinical features of the disease seem to have changed. We conducted another nationwide epidemiological survey of chronic HP in Japan to determine better estimates of the frequency and clinical features of the disease. Methods: A questionnaire was sent to qualified hospitals throughout Japan, and data on cases of chronic HP diagnosed between 2000 and 2009 were collected. Results: In total, 222 cases of chronic HP from 22 hospitals were studied. Disease subtypes included bird-related HP (1=134), summer-type HP (1=33), home-related HP (n=25), farmer's lung (n=4), isocyanate-induced HP (n=3), and other types (n=23). The median proportion of lymphocytes in bronchoalveolar lavage fluid was high (24.5%). The primary findings of computed tomography of the chest were ground-glass attenuation and interlobular septal thickening. Centidlobular fibrosis was the major pathological finding on examination of surgical lung biopsy specimens from 93 patients. The median survival time was 83 months. Conclusions: The proportion of bird-related HP was higher than that in the previous epidemiological survey, and the proportions of isocyanate-induced HP and farmer's lung were lower. A crucial step in diagnosing chronic HP is to thoroughly explore the possibility of antigen exposure. (C) 2013 The Japanese Respiratory Society. Published by Elsevier B.V. All rights reserved.

引用

页码：191 / 199

页数：9

共 29 条

[1]

New aspects of hypersensitivity pneumonitis [J].