A VERSATILE SOLID-PHASE SYNTHESIS OF N-LINKED GLYCOPEPTIDES

被引：54

作者：

VETTER, D ^{[1
]}

TUMELTY, D ^{[1
]}

SINGH, SK ^{[1
]}

GALLOP, MA ^{[1
]}

机构：

[1] AFFYMAX RES INST,PALO ALTO,CA 94304

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1995年 / 34卷 / 01期

关键词：

GLYCOPEPTIDES; PEPTIDES; SOLID-PHASE SYNTHESIS;

D O I：

10.1002/anie.199500601

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A convergent synthesis not requiring sugar protecting groups yields N‐glycopeptides. The key step is the condensation of unprotected glycosylamines with resin‐bound peptides that have activated carboxyl groups in specified positions. Twenty‐three N‐linked glycopeptides such as 1 and 2 all derived from one peptide motif were obtained. This approach should facilitate generation of glycopeptide libraries. (Formula Presented.) Copyright © 1995 by VCH Verlagsgesellschaft mbH, Germany

引用

页码：60 / 63

页数：4

共 25 条

[1]

ALBERICIO F, 1993, PEPTIDES 1992, P191

[2] CARBOHYDRATES SURGE THROUGH CLINICAL-TRIALS [J].