EFFICACY AND PHARMACOKINETICS OF A NEW CONTROLLED-RELEASE MORPHINE-SULFATE 200-MG TABLET

被引：16

作者：

HANKS, GW

HANNA, M

FINLAY, I

RADSTONE, DJ

KEEBLE, T

机构：

[1] ROYAL MARSDEN HOSP,LONDON SW3 6JJ,ENGLAND

[2] UNIV LONDON KINGS COLL HOSP,LONDON,ENGLAND

[3] HOLME TOWER MARIE CURIE CTR,CARDIFF,S GLAM,WALES

[4] WESTON PK HOSP,SHEFFIELD,S YORKSHIRE,ENGLAND

[5] ST MICHAELS HOSPICE,HEREFORD,ENGLAND

来源：

JOURNAL OF PAIN AND SYMPTOM MANAGEMENT | 1995年 / 10卷 / 01期

关键词：

CONTROLLED-RELEASE MORPHINE; HIGH-DOSE ORAL MORPHINE; PHARMACOKINETICS;

D O I：

10.1016/0885-3924(94)00067-U

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Nineteen of 25 patients (14 female) with advanced malignant disease completed a randomized controlled trial of a new high-dose (200 mg) tablet formulation of controlled-release morphine. Compared with the currently available 100-mg tablets there were no differences in pain severity or adverse effects with the new formulation. In four patients, full 12-hr plasma morphine concentration profiles at steady state were obtained and showed no significant differences between the same close provided as 100-mg and 200-mg tablets in C-max, t(max), or other pharmacokinetic indices.

引用

页码：6 / 12

页数：7

共 19 条

[1]

BROOKS I, 1989, J FAM PRACTICE, V28, P275

[2] CRITICAL EVALUATION OF THE POTENTIAL ERROR IN PHARMACOKINETIC STUDIES OF USING THE LINEAR TRAPEZOIDAL RULE METHOD FOR THE CALCULATION OF THE AREA UNDER THE PLASMA LEVEL TIME CURVE [J].