THYROCALCITONIN .2. STRUCTURE OF ALPHA- THYROCALCITONIN

被引:67
作者
NEHER, R
RINIKER, B
ZUBER, H
RITTEL, W
KAHNT, FW
机构
[1] Chemische Forschungslaboratorien, Departements Pharmazeutika, CIBA Aktiengesellschaft, Basel
[2] Schweiz Laboratorium für Molekularbiologie, Eidgenössische Technische Hochschule Zürich
关键词
D O I
10.1002/hlca.660510430
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The highly active peptide hormones isolated from pig thyroids – i.e. α‐thyrocalcitonin and its sulfoxide, containing 32 amino acid residues – were subjected to sequence studies using chemical and enzymatic methods. On the basis of these studies the following structure was derived for α‐thyrocalcitonin: (Formula Presented.) In the α‐thyrocalcitonin sulfoxide (designated formerly as β‐thyrocalcitonin) the methionine residue is replaced by methionine sulfoxide. Copyright © 1968 Verlag GmbH & Co. KGaA, Weinheim
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页码:917 / &
相关论文
共 15 条
[1]   HUMAN FIBRINOPEPTIDES ISOLATION CHARACTERIZATION AND STRUCTURE [J].
BLOMBACK, B ;
BLOMBACK, M ;
EDMAN, P ;
HESSEL, B .
BIOCHIMICA ET BIOPHYSICA ACTA, 1966, 115 (02) :371-&
[2]   ETUDE DE STRUCTURES PEPTIDIQUES LAIDE DU PHENYLISOTHIOCYANATE .4. CHROMATOGRAPHIE SUR COUCHE MINCE DE PHENYLTHIOHYDANTOINES DERIVEES DACIDES AMINES [J].
CHERBULIEZ, E ;
RABINOWICZ, J ;
BAEHLER, B .
HELVETICA CHIMICA ACTA, 1964, 47 (05) :1350-&
[3]   A PROTEIN SEQUENATOR [J].
EDMAN, P ;
BEGG, G .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1967, 1 (01) :80-&
[4]  
GRAY WR, 1963, BIOCHEM J, V89, pP59
[5]   ADDITION [J].
GRAY, WR ;
HARTLEY, BS .
BIOCHEMICAL JOURNAL, 1963, 89 (02) :379-&
[6]   FORMATION OF 3-PHENYL-2-THIOHYDANTOINS FROM PHENYLTHIOCARBAMYL AMINO ACIDS [J].
ILSE, D ;
EDMAN, P .
AUSTRALIAN JOURNAL OF CHEMISTRY, 1963, 16 (03) :411-&
[7]   THYROCALCITONIN .1. ISOLATION AND CHARACTERIZATION OF ACTIVE PEPTIDES FROM SWINE THYROID GLANDS [J].
KAHNT, FW ;
RINIKER, B ;
MACINTYRE, I ;
NEHER, R .
HELVETICA CHIMICA ACTA, 1968, 51 (01) :214-+
[8]  
LINDSAY DG, 1967, PERSONAL COMMUNICATI
[9]   EXTENDING RANGE OF APPLICATION OF EDMAN METHOD APPLICATION TO SHORT PEPTIDES IN SMALL AMOUNTS [J].
NEDKOV, P ;
GENOV, N .
BIOCHIMICA ET BIOPHYSICA ACTA, 1966, 127 (02) :541-&
[10]  
Neher R., 1963, J CHROMATOGR, V12, P329