HEREDITY OF LEUKOCYTE PHOSPHORYLASE AND AMYLO-1,6-GLUCOSIDASE DEFICIENCY

The pattern of leukocyte phosphorylase activity was studied in family members of a boy with phosphorylase-deficient glycogen storage disease; the results are best explained by assuming a sex-linked mode of inheritance. In a study of another family with a boy who had amylo-1,6-glucosidase deficiency, the leukocyte amylo-1,6-glucosidase activity was low in the cells from the proband and his mother, whereas the maternal grandparents had normal enzyme activity. © 1969 The C. V. Mosby Company.