ELECTROCHEMICAL ANALYSIS OF 3'-AZIDOTHYMIDINE (AZT)

被引：9

作者：

CZOCHRALSKA, B

SAPOK, B

SHUGAR, D

机构：

[1] Department of Biophysics, Institute of Experimental Physics., University of Warsaw, 02-089, Warsaw

来源：

NUCLEOSIDES & NUCLEOTIDES | 1990年 / 9卷 / 03期

关键词：

D O I：

10.1080/07328319008045166

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

31-Azido-3'-deoxythymidine (AZT) exhibits a two-electron diffusion--controTled polarographic reduction wave, with conversion to 31-amino-31-deoxy-thymidine. The mechanism of reduction, analytical and clinical applications, and its use for one-step synthesis of amino from azido nucleosides, are described. © 1990, Taylor & Francis Group, LLC. All rights reserved.

引用

页码：443 / 444

页数：2

共 4 条

[1]

BALZERINI J, 1988, CLIN USE ANTIVIRAL D, P362

[2]

CZICHRALSKA B, 1986, TOP CURR CHEM, V30, P133

[3] THIOL REDUCTION OF 3'-AZIDOTHYMIDINE TO 3'-AMINOTHYMIDINE - KINETICS AND BIOMEDICAL IMPLICATIONS [J].