CHEMICAL MODIFICATION OF ERYTHROMYCINS .4. SYNTHESIS AND BIOLOGICAL PROPERTIES OF 6-O-METHYLERYTHROMYCIN-B

被引:16
作者
MORIMOTO, S
ADACHI, T
MISAWA, Y
NAGATE, T
WATANABE, Y
OMURA, S
机构
[1] Research Center, Taisho Pharmaceutical Co., Ltd., Ohmiya-shi, Saitama 330
关键词
D O I
10.7164/antibiotics.43.544
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
6-O-Methylerythromycin B has been synthesized from erythromycin B via regioselective methylation of the 6-hydroxyl group in 71 % overall yield. This compound shows in vitro antibacterial activity comparable to erythromycins A and B and exhibits superior in vivo activity with improved pharmacokinetic properties. © 1990, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.
引用
收藏
页码:544 / 549
页数:6
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