INHIBITION OF TRANSLATION IN BACTERIAL AND EUKARYOTIC SYSTEMS BY THE ANTIBIOTIC ANTHELMYCIN (HIKIZIMYCIN)

被引：16

作者：

GONZALEZ, A ^{[1
]}

VAZQUEZ, D ^{[1
]}

JIMENEZ, A ^{[1
]}

机构：

[1] UNIV AUTONOMA MADRID,MADRID 34,SPAIN

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1979年 / 561卷 / 02期

关键词：

Anthelmycin; Antibiotic action; Hikizimycin; Peptide bond formation; Protein synthesis; Translation;

D O I：

10.1016/0005-2787(79)90148-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Anthelmycin inhibits protein synthesis on both pro- and eukaryotic ribosomes by preventing the peptide bond-forming reaction. The drug is structurally similar to certain other 4-aminohexosyl cytosine antibiotics including blasticidin S, gougerotin, amicetin and bamicetin although unlike these compounds anthelmycin lacks an aminoacyl moiety. It is proposed that anthelmycin inhibits the ribosomal peptidyl transferase centre by associating with a site that overlaps the (related) ribosomal receptor site(s) for the other four inhibitors. © 1979.

引用

页码：403 / 409

页数：7

共 25 条

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