DEFICIENCY OF SUPPRESSOR-INDUCER (CD4+CD45RA+) T-CELLS IN AUTISM

被引：81

作者：

WARREN, RP ^{[1
]}

YONK, LJ ^{[1
]}

BURGER, RA ^{[1
]}

COLE, P ^{[1
]}

ODELL, JD ^{[1
]}

WARREN, WL ^{[1
]}

WHITE, E ^{[1
]}

SINGH, VK ^{[1
]}

机构：

[1] UTAH STATE UNIV,DEPT BIOL,LOGAN,UT 84322

来源：

IMMUNOLOGICAL INVESTIGATIONS | 1990年 / 19卷 / 03期

关键词：

D O I：

10.3109/08820139009041839

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD4+ cells are a heterogenous population of lymphocytes including at least two distinct subpopulations: CD45RA+ cells, inducers of suppressor T cells and CDw29+cells, inducers of helper function for antibody production. To investigate the possibility that immune abnormalities in autism may involve abnormal distribution of these helper subpopulations, monoclonal antibodies were used in flow cytometric analysis to characterize peripheral blood lymphocytes of 36 subjects with autism. The autistic subjects as compared to a group of 35 healthy age-matched subjects had a significantly reduced number of lymphocytes, a decreased number of CD2+ T cells and reduced numbers of CD4+ and CD4+CD45RA+ lymphocytes. The numbers of B (CD20+ cells, suppressor T (CD8+ cells, inducers of helper function (CD4+CDw29+ and natural killer (CD56+ cells were not altered in the autistic subjects. Our results suggest that an alteration in the suppressor-inducer T-cell subset is associated with autism. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：245 / 251

页数：7

共 14 条

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