A NONINVASIVE PROCEDURE TO DETECT MUSCLE WEAKNESS IN THE MDX MOUSE

被引：66

作者：

CARLSON, CG ^{[1
]}

MAKIEJUS, RV ^{[1
]}

机构：

[1] PURDUE UNIV CALUMET,DEPT BIOL,HAMMOND,IN 46323

来源：

MUSCLE & NERVE | 1990年 / 13卷 / 06期

关键词：

isometric tension; mdx myopathy; muscle weakness; total body strength; X‐linked muscular dystrophy;

D O I：

10.1002/mus.880130603

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The forward pulling tension exerted by individual mice was measured nearly isometrically in a simple apparatus designed to determine whole body tension (WBT). WBT determinations on control (C57BI10/SnJ) and experimental (C57BI10‐mdx) mice indicate muscle weakness which lasts throughoout the lifespan of mdx mice. Direct muscle stimulation experiments in vivo also showed significant decreases in peak twitch and tetanic tensions in adult mdx muscle with no obvious alterations in twitch time course or in twitch: tetanus rations. We suggest that the noninvasive WBT procedure may be used to partially assess various therapies on this murine model of Duchenne muscular dystrophy. Copyright © 1990 John Wiley & Sons, Inc.

引用

页码：480 / 484

页数：5

共 20 条

[1] IMMUNOSTAINING OF SKELETAL AND CARDIAC-MUSCLE SURFACE-MEMBRANE WITH ANTIBODY AGAINST DUCHENNE MUSCULAR-DYSTROPHY PEPTIDE [J].