BROMFENAC, ACETAMINOPHEN, AND PLACEBO IN ORTHOPEDIC POSTOPERATIVE PAIN

被引:36
作者
MCQUAY, HJ
CARROLL, D
FRANKLAND, T
HARVEY, M
MOORE, A
机构
[1] Oxford Regional Pain Relief Unit Oxford, England
关键词
D O I
10.1038/clpt.1990.105
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
In a double-blind, placebo-controlled, single-dose, parallel-group study, oral doses (5, 10 and 25 mg) of the prostaglandin synthetase inhibitor bromfenac were compared with acetaminophen (1000 mg) and placebo for postoperative orthopedic pain. Analgesic measurements were made by nurse observers by use of standard verbal rating and visual analog scales. For most pain intensity and pain relief measurements, 1000 mg acetaminophen was statistically superior to placebo, demonstrating assay sensitivity, and 10 and 25 mg doses of bromfenac were statistically better than both placebo and 5 mg bromfenac for ordinal and analog ratings of pain intensity and pain relief; 25 mg bromfenac produced significantly longer time to remedication than acetaminophen. The 5 mg dose of bromfenac was statistically superior to placebo for some measures, including remedication time. There were no untoward adverse effects or alterations in vital signs. Overall, 10 mg bromfenac produced analgesia equivalent to that of 1000 mg acetaminophen in this pain context. © 1990.
引用
收藏
页码:760 / 766
页数:7
相关论文
共 7 条
[1]   ORAL ZOMEPIRAC AND INTRAMUSCULAR MORPHINE IN POSTOPERATIVE PAIN [J].
FORREST, WH .
JOURNAL OF CLINICAL PHARMACOLOGY, 1980, 20 (04) :259-260
[2]  
LASAGNA L, 1980, J CLIN PHARMACOL, V20, P273
[3]  
LLOYD J, 1986, ACTA PHARM TOXICO S5, V59, P197
[4]   KETOROLAC AND ACETAMINOPHEN FOR ORTHOPEDIC POSTOPERATIVE PAIN [J].
MCQUAY, HJ ;
POPPLETON, P ;
CARROLL, D ;
SUMMERFIELD, RJ ;
BULLINGHAM, RES ;
MOORE, RA .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 1986, 39 (01) :89-93
[5]   FLURADOLINE AND ASPIRIN FOR ORTHOPEDIC POSTOPERATIVE PAIN [J].
MCQUAY, HJ ;
CARROLL, D ;
POPPLETON, P ;
SUMMERFIELD, RJ ;
MOORE, RA .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 1987, 41 (05) :531-536
[6]  
MCQUAY HJ, 1988, CANCER SURV, V7, P141
[7]  
Wallenstein SL, 1975, METHODS NARCOTICS RE, P127