SIMULTANEOUS DETERMINATION OF SULFONAMIDES IN MEAT BY THERMOSPRAY LIQUID-CHROMATOGRAPHY MASS-SPECTROMETRY

被引：13

作者：

HORIE, M

SAITO, K

HOSHINO, Y

NOSE, N

TERA, M

KITSUWA, T

NAKAZAWA, H

YAMANE, Y

机构：

[1] Saitama Prefectural Institute of Public Health, Saitama 338, 639-1 Kamiokubo, Urawa

[2] Applications Department, Shimadzu Corporation, Chofu 182, 1-63-1, Shibazaki

[3] the National Institute of Public Health, Tokyo 108, 4-6-1, Shirokanedai, Minato-ku

[4] Faculty of Pharmaceutical Sciences, Chiba University, Chiba 260, 1-33, Yayoi-cho

来源：

EISEI KAGAKU-JAPANESE JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH | 1990年 / 36卷 / 04期

关键词：

liquid chromatography-mass spectrometry; meat; residual analysis; sulfonamide; thermospray;

D O I：

10.1248/jhs1956.36.283

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

A thermospray high-performance liquid chromatographic-mass spectrometric (LC-MS) method has been developed for the analysis of sulfonamides such as sulfachlorpyridazine, sulfadiazine, sulfadimethoxine, sulfadimidine, sulfadoxine, sulfamerazine, sulfamethoxazole, sulfameth-oxypyridazine, sulfamonomethoxine, sulfaquinoxaline, sulfathiazole and sulfisomidine. The LC separation was carried out on a TSK-gel ODS-80TM by using 0.05 m ammonium acetate (pH 4.5) - acetonitrile (7 :3) as the mobile phase, at a flow rate of 0.8 ml/min. The vaporizer temperature was set to 155°C and ion source block temperature to 280°C. The mass spectra obtained from sulfonamides were very simple, with base peaks corresponding to protonated molecular ions MH+. The calibration curve for sulfadimidine was rectilinear from 0.2 to 20 ng with the detection limit by selected ion monitoring (SIM) was about 100 pg. Similar results were obtained with other sulfonamides. An excellent correlation between the results of the thermospray LC-MS method and HPLC method was obtained (r = 0.981). © 1990, The Pharmaceutical Society of Japan. All rights reserved.

引用

页码：283 / 289

页数：7

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