HUMAN-LIVER ALCOHOL-DEHYDROGENASE - ENZYME ESSENTIAL TO THE METABOLISM OF DIGITALIS

被引：10

作者：

FREY, WA ^{[1
]}

VALLEE, BL ^{[1
]}

机构：

[1] HARVARD UNIV, PETER BENT BRIGHAM HOSP,SCH MED,DEPT BIOL CHEM, DIV MED BIOL,BIOPHYS RES LAB, BOSTON, MA 02115 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 91卷 / 04期

关键词：

D O I：

10.1016/0006-291X(79)91240-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human liver alcohol dehydrogenase oxidizes the 3β OH group of digitoxigenin, digoxigenin and gitoxigenin, the pharmacologically active principles of the corresponding cardiac glycosides. The oxidation products were identified by high performance liquid chromatography analysis. Ethanol and digitoxigenin are competitive, and the efficiency of their oxidation is virtually the same. Thus, liver alcohol dehydrogenase is a hitherto unknown NAD(H) dependent enzyme that performs the first and major step in the inactivation of these genins of the cardiac glycosides in the human. This could bear importantly both on the pharmacology and toxicology of digitalis therapy. © 1979.

引用

页码：1543 / 1548

页数：6

共 13 条

[1] SOME CATALYTIC PROPERTIES OF HUMAN LIVER ALCOHOL DEHYDROGENASE [J].