BIOMIMETIC ASYMMETRIC-SYNTHESIS - ENANTIOSELECTIVE WEITZ-SCHEFFER EPOXIDATION OF VITAMIN-K3 AND ANALOGS IN THE PRESENCE OF CYCLODEXTRINS

被引：39

作者：

COLONNA, S ^{[1
]}

MANFREDI, A ^{[1
]}

ANNUNZIATA, R ^{[1
]}

GAGGERO, N ^{[1
]}

CASELLA, L ^{[1
]}

机构：

[1] UNIV MILAN,CTR CNR,DIPARTIMENTO CHIM INORGAN & METALLORGAN,I-20133 MILAN,ITALY

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1990年 / 55卷 / 23期

关键词：

D O I：

10.1021/jo00310a018

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The asymmetric epoxidation of vitamin K3and analogues in aqueous alkaline buffer solution or in DMF/solid Na2CO3, in the presence of α- and β-cyclodextrin has been investigated. The enantiomeric excesses in the products were up to 48%. The various factors that control the enantioselectivity of the process have been examined. Different mechanisms are involved in aqueous medium and dipolar aprotic solvent. © 1990, American Chemical Society. All rights reserved.

引用

页码：5862 / 5866

页数：5

共 35 条

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