SOMATOSTATIN INHIBITS THE ACTIVITY OF ADENYLATE-CYCLASE IN CULTURED HUMAN MENINGIOMA CELLS AND STIMULATES THEIR GROWTH

被引:61
作者
KOPER, JW
MARKSTEIN, R
KOHLER, C
KWEKKEBOOM, DJ
AVEZAAT, CJJ
LAMBERTS, SWJ
REUBI, JC
机构
[1] ERASMUS UNIV, DEPT NEUROSURG, 3015 GD ROTTERDAM, NETHERLANDS
[2] SANDOZ PHARMA, PRECLIN RES, BASEL, SWITZERLAND
[3] SANDOZ RES INST, BERN, SWITZERLAND
关键词
D O I
10.1210/jc.74.3.543
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
It has been reported previously that most human meningiomas have receptors for somatostatin. Here we report the results of investigations of the effect of somatostatin and the somatostatin analog octreotide on the growth in vitro of human meningioma cells. Neither somatostatin nor its analog showed a direct growth inhibitory action on cultured human meningioma cells. Rather, there was a slight but significant stimulation of growth in the presence of somatostatin. The somatostatin receptors in meningioma tissue were shown to be functional since somatostatin inhibited forskolin-stimulated formation of cAMP by meninigioma membranes. In addition, cAMP inhibited the growth of cultured meningioma cells. We conclude that the stimulation by somatostatin of the growth of human meningioma cells in vitro is caused by its inhibitory effect on cAMP formation. These results suggest that therapeutic trials of patients with (recurrent) inoperable meningiomas with somatostatin analogs have to be carried out with great caution.
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收藏
页码:543 / 547
页数:5
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