AN APPROACH FOR EVALUATING AND INCREASING THE INFORMATIONAL CONTENT OF MUTAGENICITY AND CLASTOGENICITY DATA-BASES

被引：22

作者：

TAKIHI, N ^{[1
]}

ZHANG, YP ^{[1
]}

KLOPMAN, G ^{[1
]}

ROSENKRANZ, HS ^{[1
]}

机构：

[1] CASE WESTERN RESERVE UNIV, DEPT CHEM, CLEVELAND, OH 44106 USA

来源：

MUTAGENESIS | 1993年 / 8卷 / 03期

关键词：

D O I：

10.1093/mutage/8.3.257

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A method is described for using the fragments identified by the CASE structure-activity relational expert system to identify the type of chemicals that require further testing in mutagenicity and clastogenicity assays. Inclusion of such chemicals will increase the informational content of databases with respect to structural features that are under-represented in currently available data bases. The method is applied to existing databases (mutagenicity in Salmonella, chromosomal aberrations in Chinese hamster ovary celts, unscheduled DNA synthesis in rat hepatocytes, in vivo induction of micronuclei, somatic mutations in Drosophila melanogaster) to identify structural determinants that are absent.

引用

页码：257 / 264

页数：8

共 43 条

[1] CLASSIFICATION ACCORDING TO CHEMICAL-STRUCTURE, MUTAGENICITY TO SALMONELLA AND LEVEL OF CARCINOGENICITY OF A FURTHER 42 CHEMICALS TESTED FOR CARCINOGENICITY BY THE UNITED-STATES NATIONAL TOXICOLOGY PROGRAM [J].

ASHBY, J ;

TENNANT, RW ;

ZEIGER, E ;

STASIEWICZ, S .

MUTATION RESEARCH, 1989, 223 (02) :73-103

[2] FUNDAMENTAL STRUCTURAL ALERTS TO POTENTIAL CARCINOGENICITY OR NONCARCINOGENICITY [J].

ASHBY, J .

ENVIRONMENTAL MUTAGENESIS, 1985, 7 (06) :919-921

[3] DEFINITIVE RELATIONSHIPS AMONG CHEMICAL-STRUCTURE, CARCINOGENICITY AND MUTAGENICITY FOR 301 CHEMICALS TESTED BY THE UNITED-STATES NTP [J].

ASHBY, J ;

TENNANT, RW .

MUTATION RESEARCH, 1991, 257 (03) :229-306

[4] CHEMICAL-STRUCTURE, SALMONELLA MUTAGENICITY AND EXTENT OF CARCINOGENICITY AS INDICATORS OF GENOTOXIC CARCINOGENESIS AMONG 222 CHEMICALS TESTED IN RODENTS BY THE UNITED-STATES NCI/NTP [J].

ASHBY, J ;

TENNANT, RW .

MUTATION RESEARCH, 1988, 204 (01) :17-115

[5]

BRADBURY SP, 1990, ENVIRON HEALTH PERSP, V87, P181

[6] THE CLASSIFICATION OF CARCINOGENS IDENTIFIED IN THE RODENT BIOASSAY AS POTENTIAL RISKS TO HUMANS - WHAT TYPE OF SUBSTANCE SHOULD BE TESTED NEXT [J].

CLAYSON, DB ;

ARNOLD, DL .

MUTATION RESEARCH, 1991, 257 (01) :91-106

[7] REPRODUCIBILITY OF MICROBIAL MUTAGENICITY ASSAYS .1. TESTS WITH SALMONELLA-TYPHIMURIUM AND ESCHERICHIA-COLI USING A STANDARDIZED PROTOCOL [J].

DUNKEL, VC ;

ZEIGER, E ;

BRUSICK, D ;

MCCOY, E ;

MCGREGOR, D ;

MORTELMANS, K ;

ROSENKRANZ, HS ;

SIMMON, VF .

ENVIRONMENTAL MUTAGENESIS, 1984, 6 :1-251

[8] REPRODUCIBILITY OF MICROBIAL MUTAGENICITY ASSAYS .2. TESTING OF CARCINOGENS AND NONCARCINOGENS IN SALMONELLA-TYPHIMURIUM AND ESCHERICHIA-COLI [J].

DUNKEL, VC ;

ZEIGER, E ;

BRUSICK, D ;

MCCOY, E ;

MCGREGOR, D ;

MORTELMANS, K ;

ROSENKRANZ, HS ;

SIMMON, VF .

ENVIRONMENTAL MUTAGENESIS, 1985, 7 :1-248

[9] THE GENOTOXICITY OF THE ANTICANCER DRUG MITOXANTRONE IN SOMATIC AND GERM-CELLS OF DROSOPHILA-MELANOGASTER [J].

FREI, H ;

CLEMENTS, J ;

HOWE, D ;

WURGLER, FE .

MUTATION RESEARCH, 1992, 279 (01) :21-33

[10] CHROMOSOME-ABERRATIONS AND SISTER CHROMATID EXCHANGES IN CHINESE-HAMSTER OVARY CELLS - EVALUATIONS OF 108 CHEMICALS [J].

GALLOWAY, SM ;

ARMSTRONG, MJ ;

REUBEN, C ;

COLMAN, S ;

BROWN, B ;

CANNON, C ;

BLOOM, AD ;

NAKAMURA, F ;

AHMED, M ;

DUK, S ;

RIMPO, J ;

MARGOLIN, BH ;

RESNICK, MA ;

ANDERSON, B ;

ZEIGER, E .

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 1987, 10 :1-175

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