CLONING OF THE MOUSE INSULIN-RECEPTOR SUBSTRATE-1 (IRS-1) GENE AND COMPLETE SEQUENCE OF MOUSE IRS-1

被引：28

作者：

ARAKI, E

HAAG, BL

KAHN, CR

机构：

[1] HARVARD UNIV,BRIGHAM & WOMENS HOSP,DEPT MED,DIV RES,BOSTON,MA 02215

[2] HARVARD UNIV,SCH MED,JOSLIN DIABET CTR,BOSTON,MA 02215

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 1994年 / 1221卷 / 03期

关键词：

IRS-1; CDNA; (MOUSE);

D O I：

10.1016/0167-4889(94)90261-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mouse IRS-1 gene has been cloned and its structure determined. Mouse IRS-1 differs from rat by the absence of the potential C-terminal nucleotide binding site. Otherwise, the predicted IRS-1 protein is highly conserved between mouse, rat and humans, especially in the possible phosphorylation sites. The highly conserved nature of IRS-1 suggests the importance of these domains in the function of IRS-1 or its association with other proteins.

引用

页码：353 / 356

页数：4

共 14 条

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