EVIDENCE THAT THE AUTONOMIC NERVOUS-SYSTEM PLAYS A MAJOR ROLE IN THE L-NAME INDUCED HYPERTENSION IN CONSCIOUS RATS

被引：96

作者：

CUNHA, RS ^{[1
]}

CABRAL, AM ^{[1
]}

VASQUEZ, EC ^{[1
]}

机构：

[1] UFES,CBM,DEPT CIENC FISIOL,CP 780,BR-29001 VITORIA,ES,BRAZIL

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1993年 / 6卷 / 09期

关键词：

NITRIC OXIDE; N-NITRO-L-ARGININE METHYL ESTER (L-NAME); BLOOD PRESSURE; GANGLIONIC BLOCKADE; HYPERTENSION;

D O I：

10.1093/ajh/6.9.806

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

The present study was designed to investigate the role of the autonomic nervous system in experimental hypertension induced by chronic administration of N-nitro-L-arginine methyl ester (L-NAME) in the drinking water (1 mg/mL) over 6 days. L-NAME ingestion caused a large rise in resting mean arterial pressure (MAP) (175 +/- 5 mm Hg) and heart rate (HR) (440 +/- 17 beats per minute) compared to nontreated control rats (resting MAP: 112 +/- 2 mm Hg and HR: 345 +/- 8 beats per minute). Ganglionic blockade induced by trimethaphan (5 mg/kg, intravenously) caused a significantly (P < .01) greater decrease in MAP (DELTA - 86 +/- 7 mm Hg) compared to control rats MAP (DELTA - 44 +/- 4 mm Hg). This strongly suggests that the level of central sympathetic tone in L-NAME - treated rats is much greater than in nontreated rats. Using atenolol and atropine alone and combined, the level of resting sympathetic drive to the heart was found to be significantly increased in L-NAME - treated rats compared to control rats. However, vagal tone to the heart was found to be virtually abolished in L-NAME - treated rats compared to control rats. These results indicate that an increase in central sympathetic drive plays an important role in the hypertension induced by chronic inhibition of nitric oxide synthesis with L-NAME.

引用

页码：806 / 809

页数：4

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