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GET RECEPTIVE TO METABOTROPIC GLUTAMATE RECEPTORS

被引：122
作者：
PIN, JP
BOCKAERT, J
机构：
[1] UPR-9023, Mécanismes Moléculaires des Communications Cellulaires, CCIPE, 34094 Montpellier Cedex 5, Rue de la Cardonille
来源：
CURRENT OPINION IN NEUROBIOLOGY | 1995年 / 5卷 / 03期
关键词：
D O I：
10.1016/0959-4388(95)80047-6
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Glutamate activates not only ionotropic glutamate receptors, but also G-protein-coupled receptors, called metabotropic glutamate receptors. Recent studies have revealed that these metabotropic receptors share distinctive structural properties and that they form a subgroup within the heptahelical receptor family. The development of ligands that bind specifically to these receptors has provided a means of characterizing the important roles they play in the tuning of fast synaptic transmission, including the induction of long-term changes in synaptic strength. Their involvement in the control of movement, spatial and olfactory memory and nociception has recently been demonstrated.
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页码：342 / 349
页数：8
相关论文
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