NEW ASPECTS OF THE PHYSIOLOGICAL SIGNIFICANCE OF NAD, POLY ADP-RIBOSE AND CYCLIC ADP-RIBOSE

被引：25

作者：

OKAMOTO, H

TAKASAWA, S

TOHGO, A

机构：

[1] Department of Biochemistry, Tohoku University School of Medicine, Sendai

来源：

BIOCHIMIE | 1995年 / 77卷 / 05期

关键词：

ADP-RIBOSYL CYCLASE; CYCLIC ADP-RIBOSE HYDROLASE; CD38; INSULIN;

D O I：

10.1016/0300-9084(96)88146-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cyclic ADP-ribose is generated from NAD(+) in glucose-stimulated beta-cells by CD38. Cyclic ADP-ribose mobilizes Ca2+ from the endoplasmic reticulum to secrete insulin. The amino acid residues of Cys-119 and Cys-201 in CD38 are essential for the synthesis and hydrolysis of cyclic ADP-ribose.

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页码：356 / 363

页数：8

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