BIOLOGICAL EFFECT OF INTERFERON-GAMMA DURING THE COURSE OF EXPERIMENTAL-INFECTION OF RAT BY SCHISTOSOMA-MANSONI

被引：6

作者：

PANCRE, V ^{[1
]}

SCHELLEKENS, H ^{[1
]}

VANDERMEIDE, P ^{[1
]}

VORNG, H ^{[1
]}

DELANOYE, A ^{[1
]}

CAPRON, A ^{[1
]}

AURIAULT, C ^{[1
]}

机构：

[1] TNO,CTR PRIMATE,2280 HV RIJSWIJK,NETHERLANDS

来源：

CELLULAR IMMUNOLOGY | 1990年 / 125卷 / 01期

关键词：

D O I：

10.1016/0008-8749(90)90062-V

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We demonstrate here that a second mechanism of platelet activation dependent on lymphokine could also take place in the expression of platelet cytotoxicity against Schistosoma mansoni in vitro. Indeed, IgE, as previously described, but also IFN-γ, present in the sera of infected rats, together induce platelets from normal rats into cytotoxic effectors for the parasitic larvae. This second mechanism appears also effective in vivo since the passive transfer of normal platelets treated by recombinant IFN-γ (rIFN-γ) and the administration of rIFN-γ to rats conferred a protective immunity to S. mansoni. © 1990.

引用

页码：58 / 64

页数：7

共 21 条

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