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COMPARATIVE PHENOTYPES IN RHABDOMYOSARCOMAS AND DEVELOPING SKELETAL-MUSCLE

被引：37
作者：
CARTER, RL
JAMESON, CF
PHILP, ER
PINKERTON, CR
机构：
[1] ROYAL MARSDEN HOSP,INST CANC RES,MED PAEDIAT SECT,SUTTON SM2 5PT,SURREY,ENGLAND
[2] ROYAL MARSDEN HOSP,DEPT HISTOPATHOL,SUTTON SM2 5PT,SURREY,ENGLAND
[3] ST HELIER HOSP,DEPT HISTOPATHOL,CARSHALTON SM5 1AA,SURREY,ENGLAND
来源：
HISTOPATHOLOGY | 1990年 / 17卷 / 04期
关键词：
developing skeletal muscle; immunohistochemistry; rhabdomyosarcoma;
D O I：
10.1111/j.1365-2559.1990.tb00733.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The morphological and immunohistochemical phenotypes of 51 rhabdomyosarcomas from young people have been described and contrasted with phenotypes in developing skeletal muscle from 20 fetuses and neonates. The tumours express markers in a cumulative and consistent sequence—vimentin, desmin, fast myosin, myoglobin—which evolves pari passu with morphological differentiation and follows the same pattern found in normal myogenesis. Changes in immunohistochemical phenotype are documented in residual and recurrent tumours excised after chemotherapy. The presumptive rhabdomyoblastic nature of some primitive tumours, marking with vimentin alone, is discussed. Copyright © 1990, Wiley Blackwell. All rights reserved
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页码：301 / 309
页数：9
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