THE INFLUENCE OF AGE ON RENAL PROSTAGLANDIN SYNTHESIS IN MAN

被引：17

作者：

HORNYCH, A ^{[1
]}

FORETTE, F ^{[1
]}

BARIETY, J ^{[1
]}

KRIEF, C ^{[1
]}

AUMONT, J ^{[1
]}

PARIS, M ^{[1
]}

机构：

[1] BROCA HOSP,F-75013 PARIS,FRANCE

来源：

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 1991年 / 43卷 / 03期

关键词：

D O I：

10.1016/0952-3278(91)90168-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The purpose of our study was to determine influence of age on renal prostaglandin (PG) synthesis in man. Urinary prostaglandins 6-Keto-PGF1-alpha, TxB2, PGE2 and PGF2-alpha were measured in 45 normotensive subjects aged from 20-95 years. Urinary 6-Keto-PGF1-alpha excretion, reflecting mainly renal cortical prostacyclin synthesis, decreased significantly with age, while urinary TxB2 showed the opposite development. The ratio of urinary 6-Keto-PGF1-alpha/TxB2 decreased with age. PGE2 excretion was preserved in old subjects probably because the age-dependent decrease in renal function concerns mainly the cortex and spares the medulla. PGF2-alpha synthesis was least influenced by age. This age-dependent decrease in renal prostacyclin synthesis may play a role in the renal alterations of the elderly.

引用

页码：191 / 195

页数：5

共 28 条

[1] SERUM CREATININE DETERMINATION WITHOUT PROTEIN PRECIPITATION [J].