ATRIAL-NATRIURETIC-PEPTIDE INHIBITS THE SPONTANEOUS CONTRACTIONS OF RABBIT ISOLATED ILEUM

被引：6

作者：

BLANDIZZI, C ^{[1
]}

AGEN, C ^{[1
]}

NATALE, G ^{[1
]}

DELTACCA, M ^{[1
]}

机构：

[1] UNIV PISA,SCH MED & DENT,INST MED PHARMACOL,VIA ROMA 55,I-56126 PISA,ITALY

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1992年 / 44卷 / 07期

关键词：

D O I：

10.1111/j.2042-7158.1992.tb05477.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The present study investigates the effects of atriopeptin II on spontaneous phasic contractions of rabbit isolated ileum. Atriopeptin II caused a significant and concentration-dependent decrease in ileum motor activity. This effect was mimicked by 8-Br-cGMP and it was not affected by pretreatment with tetrodotoxin. Verapamil significantly decreased ileum contractions; however, in the presence of this calcium blocker, atriopeptin II further reduced ileal motility. These findings demonstrate that atriopeptin II depresses the motility of rabbit ileum through a cGMP-dependent mechanism and suggest that neither ileal neural networks nor extracellular calcium are involved in this effect.

引用

页码：615 / 617

页数：3

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