CONFORMATIONAL AND DYNAMIC CHANGES OF D-TRYPTOPHAN AND L-TRYPTOPHAN DUE TO STEREOSELECTIVE INTERACTION WITH HUMAN SERUM-ALBUMIN, AS REVEALED BY PROTON-SELECTIVE RELAXATION RATE MEASUREMENTS

被引：29

作者：

UCCELLOBARRETTA, G ^{[1
]}

BERTUCCI, C ^{[1
]}

DOMENICI, E ^{[1
]}

SALVADORI, P ^{[1
]}

机构：

[1] CNR,CTR MACROMOLEC STEREORDINATE & OTTICAMENTE ATTIVE,DIPARTIMENTO CHIM & CHIM IND,I-56126 PISA,ITALY

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1991年 / 113卷 / 18期

关键词：

D O I：

10.1021/ja00018a046

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The proton selective relaxation rates of D- and L-tryptophan are affected to a different extent by the interaction with human serum albumin. These differences are correlated to a different degree of immobilization of the two enantiomers at the protein binding site. Conversely, no differences are detected in their intermolecular dipolar interaction with the protein protons.

引用

页码：7017 / 7019

页数：3

共 16 条

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