DOUBLE ALKYLATION OF CARBON-MONOXIDE VIA FREE-RADICALS - SYNTHESIS OF UNSYMMETRICAL KETONES

被引：60

作者：

RYU, IH

KUSANO, K

YAMAZAKI, H

SONODA, N

机构：

[1] Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1991年 / 56卷 / 17期

关键词：

D O I：

10.1021/jo00017a001

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel method for the synthesis of unsymmetrical ketones via the free radical carbonylation of alkyl halides is described. The mechanism of the reaction involves the trapping of an alkyl free radical by CO, the addition of the acyl free radical so formed to an alkene, and termination of the reaction by the abstraction of a hydrogen atom from tributyltin hydride by the product acyl-substituted free radical.

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页码：5003 / 5005

页数：3

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