CORTICOBASAL DEGENERATION - DECREASED AND ASYMMETRICAL GLUCOSE CONSUMPTION AS STUDIED WITH PET

被引：88

作者：

BLIN, J

VIDAILHET, MJ

PILLON, B

DUBOIS, B

FEVE, JR

AGID, Y

机构：

[1] Service de Neurologie et Neuropsychologie, Hôpital de la Salpêtrière, Paris

[2] Service Hospitalier Frédéric Joliot, DRIPP, CEA, Hôpital d'Orsay, Orsay

[3] Service de Neurologie, Hôpital Laennec, Nantes

来源：

MOVEMENT DISORDERS | 1992年 / 7卷 / 04期

关键词：

CORTICOBASAL DEGENERATION; POSITRON EMISSION TOMOGRAPHY; FLUORODEOXYGLUCOSE; APRAXIA;

D O I：

10.1002/mds.870070409

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Cerebral energy metabolism was studied by positron emission tomography and [F-18]fluorodeoxyglucose in five patients with clinical diagnoses of probable corticobasal degeneration. A reduction in glucose consumption was observed in most cortical and subcortical structures compared to age-matched controls. The reduction was greatest on the side of the brain contralateral to the most affected limbs, as shown by the significantly lower ratios of contralateral to homolateral metabolic rates, in the temporal and sensorimotor cortex of patients compared to controls. A distinct asymmetry between the two hemispheres could be observed in a patient who was examined twice in the course of his illness. Detection of this asymmetrical decrease in brain cortical and subcortical glucose metabolism may prove useful as additional evidence supporting clinical diagnoses of the disease.

引用

页码：348 / 354

页数：7

共 35 条

[1]

Case records of the Massachussets General Hospital 1985. Case 38‐1985, N Engl J Med, 313, pp. 739-748, (1985)

[2]

Riley DE, Lang AE., Corticobasal ganglionic degeneration: further observations in six additional cases, Neurology, 38, (1988)

[3]

Watts RL, Williams RS, Growdon JD, Et al., Corticobasal ganglionic degeneration [Abstract], Neurology, 35, (1985)

[4]

Gibb WRG, Luthert PJ, Marsden CD., Corticobasal degeneration, Brain, 112, pp. 1171-1192, (1989)

[5]

Watts RL, Mirra SS, Young RR, Burger PC, Villier JA, Heyman A., Corticobasal ganglionic degeneration with neuronal achromasia: clinical pathological study of 2 cases [Abstract], Neurology, 39, (1989)

[6]

Rebeiz JJ, Kolodny EH, Richardson EP., Corticodentatonigral degeneration with neuronal achromasia, Arch Neurol, 18, pp. 20-33, (1968)

[7]

Riley DE, Lang AE, Lewis A, Resch L, Ashby P, Hornykiewicz O, Black S., Cortico‐basal ganglionic degeneration, Neurology, 40, pp. 1203-1212, (1990)

[8]

Sawle GV, Brooks DJ, Marsden CD, Frackowiack RJ., Corticobasal degeneration. A unique pattern of regional cortical oxygen hypometabolism and striatal fluorodopa uptake demonstrated by positron emission tomography, Brain, 114, pp. 541-556, (1991)

[9]

Eidelberg D, Modeller JR, Sidtis JJ, Et al., Corticodentatonigral degeneration: metabolic asymmetries studied with 18F‐fluorodeoxyglucose and positron emission tomography [Abstract], Neurology, 39, (1989)

[10]

Lhermitte F, Pillon B, Serdaru M., Imitation and utilization behaviours: neuropsychological study of 75 cases, Ann Neurol, 19, pp. 326-334, (1986)

← 1 2 3 4 →