REPEATED METHAMPHETAMINE-TREATMENT ALTERS BRAIN SIGMA RECEPTORS

被引：35

作者：

ITZHAK, Y

机构：

[1] Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, Miami

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1993年 / 230卷 / 02期

关键词：

METHAMPHETAMINE; SIGMA RECEPTORS; PSYCHOSIS;

D O I：

10.1016/0014-2999(93)90810-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The present study was undertaken to examine whether repeated exposure of rats to the psychostimulant drug, methamphetamine, induces changes in sigma receptor binding. A significant up-regulation (130-145% of control B(max)) of sigma receptors, labeled with [H-3]pentazocine, was observed in the substantia nigra, frontal cortex and cerebellum of rats treated with methamphetamine (4.0 mg/kg per day; 10 days). These findings suggest that methamphetamine-induced psychosis may be associated with the up-regulation of sigma receptors in critical brain regions.

引用

页码：243 / 244

页数：2

共 5 条

[1] SIGMA-BINDING SITES IN THE BRAIN - AN EMERGING CONCEPT FOR MULTIPLE SITES AND THEIR RELEVANCE FOR PSYCHIATRIC-DISORDERS [J].