SPECIFICITY OF THE ANTICOLLAGENASE ACTION OF TETRACYCLINES - RELEVANCE TO THEIR ANTIINFLAMMATORY POTENTIAL

被引：101

作者：

SUOMALAINEN, K

SORSA, T

GOLUB, LM

RAMAMURTHY, N

LEE, HM

UITTO, VJ

SAARI, H

KONTTINEN, YT

机构：

[1] SUNY STONY BROOK,DEPT ORAL BIOL & PATHOL,STONY BROOK,NY 11794

[2] UNIV HELSINKI,DEPT PERIODONTOL,SF-00100 HELSINKI 10,FINLAND

[3] UNIV HELSINKI,DEPT MED CHEM,SF-00100 HELSINKI 10,FINLAND

[4] UNIV HELSINKI,CENT HOSP,DEPT MED 4,SF-00100 HELSINKI 10,FINLAND

[5] UNIV BRITISH COLUMBIA,DEPT ORAL BIOL,VANCOUVER V6T 1W5,BC,CANADA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1992年 / 36卷 / 01期

关键词：

D O I：

10.1128/AAC.36.1.227

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The concentrations of doxycycline and 4-de-dimethylaminotetracycline required to inhibit 50% of collagenase activity were found to be 15 to 30-mu-M for human neutrophil and gingival crevicular fluid collagenases. Fibroblast collagenase was relatively resistant to inhibition by tetracyclines; the 50% inhibitory concentrations of doxycycline and 4-de-dimethylaminotetracycline were 280 and 510-mu-M, respectively.

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页码：227 / 229

页数：3

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