MATCHING LOCALIZATION OF VASOACTIVE INTESTINAL POLYPEPTIDE (VIP) AND VIP-RECEPTOR AT PRESYNAPTIC AND POSTSYNAPTIC SITES IN THE MOUSE VISUAL-CORTEX

被引：5

作者：

CSILLAG, A

HAJOS, F

ZILLES, K

SCHLEICHER, A

SCHRODER, H

机构：

[1] UNIV VET SCI BUDAPEST,DEPT ANAT & HISTOL,H-1078 BUDAPEST 7,HUNGARY

[2] UNIV COLOGNE,INST ANAT 2,W-5000 COLOGNE 41,GERMANY

[3] UNIV DUSSELDORF,C&O VOGT INST BRAIN RES,W-4000 DUSSELDORF 1,GERMANY

来源：

JOURNAL OF NEUROCYTOLOGY | 1993年 / 22卷 / 06期

关键词：

D O I：

10.1007/BF01181568

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

Vibratome sections of the mouse occipital cortex were processed by double label immunohistochemistry to demonstrate the localization of the receptor for vasoactive intestinal polypeptide and the peptide itself. The receptor was found to be distributed in the cytoplasm and major dendrites of numerous cortical cells, mainly pyramidal neurons. Vasoactive intestinal polypeptide, on the other hand, occurred in a population of non-pyramidal neurons and axonal boutons. Image analysis revealed a close spatial association of peptide-containing presynaptic terminals with receptor-containing cells. Ultrastructurally, these connections represented symmetrical axo-somatic and axo-dendritic synapses. Our findings demonstrate a matching histological localization of vasoactive intestinal polypeptide and its receptor in the brain.

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收藏

页码：491 / 497

页数：7

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