LIPASE-CATALYZED ENANTIOSELECTIVE SYNTHESIS OF OPTICALLY-ACTIVE MEPHOBARBITAL, HEXOBARBITAL AND FEBARBAMATE

被引:9
作者
MURATA, M [1 ]
UCHIDA, H [1 ]
ACHIWA, K [1 ]
机构
[1] UNIV SHIZUOKA, SCH PHARMACEUT SCI, 395 YADA, SHIZUOKA 422, JAPAN
关键词
LIPASE; HYDROLYSIS; ORGANIC SOLVENT; ASYMMETRIC SYNTHESIS; N-ACYLOXYMETHYL GROUP; CHIRAL BARBITURATE; MEPHOBARBITAL; HEXOBARBITAL; FEBARBAMATE;
D O I
10.1248/cpb.40.2605
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Chiral 5,5-disubstituted N-acyloxymethylbarbiturates have been obtained in 40-99% optical yields by lipase-catalyzed hydrolyses of 5,5-disubstituted N,N'-bisacyloxymethylbarbiturates in H2O-saturated diisopropyl ether. These chiral barbiturates were readily converted into chiral drugs, mephobarbital, hexobarbital and febarbamate.
引用
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页码:2605 / 2609
页数:5
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