GENERATION AND PROPAGATION OF ECTOPIC BEATS INDUCED BY SPATIALLY LOCALIZED NA-K PUMP INHIBITION IN ATRIAL NETWORK MODELS

被引：63

作者：

WINSLOW, RL

VARGHESE, A

NOBLE, D

ADLAKHA, C

HOYTHYA, A

机构：

[1] UNIV MINNESOTA, ARMY HIGH PERFORMANCE COMP RES CTR, MINNEAPOLIS, MN 55455 USA

[2] UNIV OXFORD, PHYSIOL LAB, OXFORD OX1 3PJ, OXON, ENGLAND

[3] MIT, DEPT ELECT ENGN, CAMBRIDGE, MA 02139 USA

来源：

PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES | 1993年 / 254卷 / 1339期

基金：

英国惠康基金;

关键词：

D O I：

10.1098/rspb.1993.0126

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A biophysically detailed two-dimensional network model of the cardiac atrium has been implemented on the Thinking Machines massively parallel CM-5 supercomputer. The model is used to study the effects of spatially localized inhibition of the Na-K pump. Na overloading produced by pump inhibition can induce spontaneous, propagating ectopic beats within the network. At a cell-to-cell coupling value yielding a realistic plane wave conduction velocity of 0.6 m s(-1), pump inhibition in roughly 1000 cells can induce propagating ectopic beats in a 512 x 512 lattice of cells.

引用

页码：55 / 61

页数：7

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