EFFECT OF INTERFERON THERAPY ON SERUM HEPATITIS-C VIRUS-RNA LEVELS IN CHILDREN WITH CHRONIC HEPATITIS-C

被引：6

作者：

FUJISAWA, T ^{[1
]}

OHKAWA, T ^{[1
]}

INUI, A ^{[1
]}

YOKOTA, S ^{[1
]}

机构：

[1] YOKOHAMA CITY UNIV,SCH MED,DEPT PEDIAT,YOKOHAMA,KANAGAWA 232,JAPAN

来源：

INTERNATIONAL HEPATOLOGY COMMUNICATIONS | 1994年 / 2卷 / 06期

关键词：

MULTICYCLIC RT-PCR; MALIGNANCY; HCV GENOTYPE;

D O I：

10.1016/0928-4346(94)90026-4

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The majority of chronic hepatitis C in children was related to blood transfusion. We evaluated the efficacy and safety of interferon (IFN) treatment on 12 children with chronic hepatitis C who had serious underlying diseases. Natural IFN-alpha was administered in a dosage of 0.1 MIU/kg daily for 2 weeks and then three times a week for an additional 22 weeks. serum HCV RNA levels, determined by multicyclic RT-PCR, were elevated in all subjects before treatments: the HCV RNA level was above 10(7) copies/ml in 11 (91.7%) of 12 cases. After 24 weeks of therapy, HCV RNA was undetectable in all subjects. IFN was well tolerated by all children. Our results indicate that this IFN therapy is both beneficial and safe in children with chronic hepatitis C.

引用

页码：316 / 320

页数：5

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